Microfiber uppers are a great choice if you're looking for a performance-oriented shoe that balances comfort, breathability, and durability. Compared to synthetic leather, microfiber is softer against your foot, lighter in weight, and tends to hold its shape better over many miles of riding. That's why you'll find it in most mid-to-high-end race and performance shoes.
The real advantage shows up on longer rides, where a softer, more conforming upper reduces hot spots and pressure points without sacrificing structure. Microfiber breathes reasonably well—though not as freely as mesh or knit—and it won't soak up water the way real leather can.
If you're a road rider, gravel racer, or anyone putting in serious miles, microfiber hits a sweet spot between the durability of synthetic leather and the premium feel of higher-end materials. For casual commuting or budget-conscious riding, synthetic leather will serve you just fine, but for performance-focused cycling, microfiber is usually worth the upgrade.