Synthetic leather is a great all-around choice for most riders. It's durable, holds its shape well over time, and is easy to clean after muddy rides or wet commutes. You'll find it commonly used in mid-range road and mountain bike shoes because it strikes a solid balance between structure and comfort.
The main trade-off is breathability. Synthetic leather offers moderate ventilation, so it's comfortable in mild to warm conditions but may feel hot on scorching summer days where mesh or knit uppers would be better. It's also not waterproof, so if you regularly ride in rain or cold, you might want to consider a GORE-TEX option instead.
Choose synthetic leather if you want a low-maintenance, long-lasting shoe for general road riding, mountain biking, or commuting in typical conditions. It's especially good if you prioritize durability and easy care over maximum breathability or weather protection.